Before when I played keyboard only, I used the same setup. I had no problem circling my opponents or strafe while running. You see if you circle an enemy you use key-3 and key-4 or key-1 and key-6, no problem there because you can easily use different fingers for those keys.
In newer games with smarter AI's that can predict where you're gonna be in a millisecond if you continue moving in the same direction, the setup becomes more useless though.
: How do you manage being able to circle your opponents? Effective vidding
: requires the ability to sidestep and turn at the same time so that you can
: fist them without taking damage. Even in conventional play, being able to
: fire at your opponent while sidesteppng out of the way of their
: projectiles gives you a significant advantage, but you can't do this
: repeatedly unless you turn at the same time. And how about straif-running
: - running foward and sidestepping at the same time?